Publication, Part of Medicines and Pregnancy Registry
[MI] Medicines and Pregnancy Registry - Antiepileptic use in females aged 0 to 54 in England: April 2018 to March 2024
Findings
Valproate and pregnancy
Of the 54,098 females prescribed valproate,
1,659 females included in the valproate register have had a pregnancy since April 2018 (this includes records of births since April 2018, and therefore includes conceptions that occurred prior to April 2018). Of which, 1,473 females on the register have a record of conception since April 2018.
1,197 females did not receive valproate prescriptions during pregnancy
of which 916 females on the register stopped receiving prescriptions for valproate prior to pregnancy and did not restart after pregnancy, within the reporting period.
345 females on the register were prescribed valproate during their pregnancy.
Of which, 11 were identified as new additions in the most recent 6 months, October 2023 to March 2024. 29 females on the register were prescribed valproate within their pregnancy period and had not been prescribed valproate within the previous 12 months and are therefore classed as a new starter. Of these, there were no new starters in the most recent 6 months, October 2023 to March 2024.
Topiramate and pregnancy
Of the 145,139 females prescribed topiramate,
18,482 females included in the topiramate register have had a pregnancy since April 2018 (this includes records of births since April 2018, and therefore includes conceptions that occurred prior to April 2018). Of which, 16,269 females on the register have a record of conception since April 2018.
14,466 females did not receive topiramate prescriptions during pregnancy.
Of which, 7,648 females on the register stopped receiving prescriptions for topiramate prior to pregnancy and did not restart after pregnancy, within the reporting period
2,411 females on the register were prescribed topiramate during their pregnancy.
Of which, 158 were identified as new additions in the most recent 6 months, October 2023 to March 2024. 413 females on the register were prescribed topiramate within their pregnancy period and had not been prescribed topiramate within the previous 12 months and are therefore classed as a new starter. Of these, 27 are new starters in the most recent 6 months, October 2023 to March 2024.
Last edited: 10 September 2024 12:33 pm