Publication, Part of Medicines and Pregnancy Registry
[MI] Medicines and Pregnancy Registry - Antiepileptic use in females aged 0 to 54 in England: April 2018 to September 2023
Findings
Valproate and pregnancy
Of the 53,395 females prescribed valproate,
1,536 females included in the valproate register have had a pregnancy since April 2018 (this includes records of births since April 2018, and therefore includes conceptions that occurred prior to April 2018). Of which, 1,356 females on the register have a record of conception since April 2018.
1,087 females did not receive valproate prescriptions during pregnancy
of which 850 females on the register stopped receiving prescriptions for valproate prior to pregnancy and did not restart after pregnancy, within the reporting period.
334 females on the register were prescribed valproate during their pregnancy.
Of which, 17 were identified as new additions in the most recent 6 months, April 2023 to September 2023. 29 females on the register were prescribed valproate within their pregnancy period and had not been prescribed valproate within the previous 12 months and are therefore classed as a new starter. Of these, 2 are new starters in the most recent 6 months, April 2023 to September 2023.
Topiramate and pregnancy
Of the 136,672 females prescribed topiramate,
16,253 females included in the topiramate register have had a pregnancy since April 2018 (this includes records of births since April 2018, and therefore includes conceptions that occurred prior to April 2018). Of which, 14,191 females on the register have a record of conception since April 2018.
12,455 females did not receive topiramate prescriptions during pregnancy.
Of which, 6,760 females on the register stopped receiving prescriptions for topiramate prior to pregnancy and did not restart after pregnancy, within the reporting period
2,252 females on the register were prescribed topiramate during their pregnancy.
Of which, 189 were identified as new additions in the most recent 6 months, April 2023 to September 2023. 385 females on the register were prescribed topiramate within their pregnancy period and had not been prescribed topiramate within the previous 12 months and are therefore classed as a new starter. Of these, 29 are new starters in the most recent 6 months, April 2023 to September 2023.
Last edited: 22 March 2024 2:34 pm