Publication, Part of Medicines and Pregnancy Registry
[MI] Medicines and Pregnancy Registry - Antiepileptic use in females aged 0 to 54 in England: April 2018 to March 2025
Findings
Valproate and pregnancy
Of the 55,123 females prescribed valproate,
1,870 females included in the valproate register have had a pregnancy since April 2018 (this includes records of births since April 2018, and therefore includes conceptions that occurred prior to April 2018). Of which, 1,683 females on the register have a record of conception since April 2018.
1,397 females did not receive valproate prescriptions during pregnancy
of which 1,068 females on the register stopped receiving prescriptions for valproate prior to pregnancy and did not restart after pregnancy, within the reporting period.
363 females on the register were prescribed valproate during their pregnancy.
Of which, 5 were identified as new additions in the most recent 6 months, October 2024 to March 2025. 30 females on the register were prescribed valproate within their pregnancy period and had not been prescribed valproate within the previous 12 months and are therefore classed as a new starter. Of these, none are new starters in the most recent 6 months, October 2024 to March 2025.
Topiramate and pregnancy
Of the 157,172 females prescribed topiramate,
22,461 females included in the topiramate register have had a pregnancy since April 2018 (this includes records of births since April 2018, and therefore includes conceptions that occurred prior to April 2018). Of which, 20,079 females on the register have a record of conception since April 2018.
18,195 females did not receive topiramate prescriptions during pregnancy.
Of which, 9,691 females on the register stopped receiving prescriptions for topiramate prior to pregnancy and did not restart after pregnancy, within the reporting period
2,668 females on the register were prescribed topiramate during their pregnancy.
Of which, 89 were identified as new additions in the most recent 6 months, October 2024 to March 2025. 455 females on the register were prescribed topiramate within their pregnancy period and had not been prescribed topiramate within the previous 12 months and are therefore classed as a new starter. Of these, 10 are new starters in the most recent 6 months, October 2024 to March 2025.
Last edited: 23 September 2025 10:28 am