Part of Cancer staging guidance sheets
Merkel cell carcinoma of skin (ICD10 C44 & C63.2)
Introduction
This is the data sheet for TNM 8th edition staging of the merkel cell carcinoma of skin (ICD10 C44 & C63.2)
For more detailed information regarding TNM staging, please see pages 147-149 of the UICC TNM 8 book or visit the Wiley and UICC website.
Stage groupings
Clinical stage
|
Stage Group |
T stage |
N stage |
M stage |
|---|---|---|---|
|
Stage 0 |
Tis |
N0 |
M0 |
|
Stage I |
T1 |
N0 |
M0 |
|
Stage IIA |
T2, T3 |
N0 |
M0 |
|
Stage IIB |
T4 |
N0 |
M0 |
|
Stage III |
Any T |
N1, N2, N3 |
M0 |
|
Stage IV |
Any T |
Any N |
M1 |
|
Stage IV |
Any T |
Any N |
M1 |
Pathological stage
|
Stage 0 |
Tis |
N0 |
M0 |
|---|---|---|---|
|
Stage I |
T1 |
N0 |
M0 |
|
Stage IIA |
T2, T3 |
N0 |
M0 |
|
Stage IIB |
T4 |
N0 |
M0 |
|
Stage IIIA |
T0 |
N1b |
M0 |
|
|
T1, T2, T3, T4 |
N1a, N1a(sn) |
M0 |
|
Stage IIIB |
Any T |
N1b, N2, N3 |
M0 |
|
Stage IV |
Any T |
Any N |
M1 |
TNM clinical classification
T - primary tumour
| T value | Description |
|---|---|
|
TX |
Primary tumour cannot be assessed |
|
T0 |
No evidence of primary tumour |
|
Tis |
Carcinoma in situ |
|
T1 |
Tumour 2 cm or less in greatest dimension |
|
T2 |
Tumour more than 2 cm but not more than 5 cm in greatest dimension |
|
T3 |
Tumour more than 5 cm in greatest dimension |
|
T4 |
Tumour invades deep extradermal structures, i.e., cartilage, skeletal muscle, fascia or bone |
N - regional lymph nodes
| N value | Description |
|---|---|
|
NX |
Regional lymph nodes cannot be assessed |
|
N0 |
No regional lymph node metastasis |
|
N1 |
Regional lymph node metastasis |
|
N2 |
In‐transit metastasis without lymph node metastasis |
|
N3 |
In‐transit metastasis with lymph node metastasis |
Note:
In‐transit metastasis: a discontinuous tumour distinct from the primary lesion and located between the primary lesion and the draining regional lymph nodes or distal to the primary lesion.
M - distant metastasis
| M value | Description |
|---|---|
|
M0 |
No distant metastasis |
|
M1 |
Distant metastasis M1a - Skin, subcutaneous tissues or non‐regional lymph node(s) M1b - Lung M1c - Other site(s) |
TNM pathological classification
pT - primary tumour
The pT categories correspond to the T categories as per above.
pN - regional lymph nodes
| pN value | Description |
|---|---|
|
pN0 |
Histological examination of a regional lymphadenectomy specimen will ordinarily include 6 or more lymph nodes. If the lymph nodes are negative, but the number ordinarily examined is not met, classify as pN0. |
|
pNX |
Regional lymph nodes cannot be assessed |
|
pN0 |
No regional lymph node metastasis |
|
pN1 |
Regional lymph node metastasis pN1a - (sn)Microscopic metastasis detected on sentinel node biopsy pN1a - Microscopic metastasis detected on node dissection pN1b - Macroscopic metastasis (clinically apparent) |
|
pN2 |
In‐transit metastasis without lymph node metastasis |
|
pN3 |
In‐transit metastasis with lymph node metastasis |
Note:
In‐transit metastasis: a discontinuous tumour distinct from the primary lesion and located between the primary lesion and the draining regional lymph nodes or distal to the primary lesion.
Last edited: 21 December 2022 4:53 pm
