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Pleural mesothelioma (ICD10 C45)

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Introduction

This is the data sheet for TNM 8th edition staging of the pleural mesothelioma (ICD10 C45)

For more detailed information regarding TNM staging, please see pages 113-114 of the UICC TNM 8 book or visit the Wiley and UICC website.

Stage groupings

Stage Group

T stage

N stage

M stage

Stage IA

T1

N0

M0

Stage IB

T2, T3

N0

M0

Stage II

T1, T2

N1

M0

Stage IIIA

T3

N1

M0

Stage IIIB

T1, T2, T3

N2

M0

 

T4

Any N

M0

Stage IV

Any T

Any N

M1

TNM clinical classification

T - primary tumour

T value Description

TX

Primary tumour cannot be assessed

T0

No evidence of primary tumour

T1

Tumour involves ipsilateral parietal pleura, with or without involvement of visceral, mediastinal or diaphragmatic pleura.

T2

Tumour involves the ipsilateral pleura (parietal or visceral pleura), with at least one of the following:

  • invasion of diaphragmatic muscle
  • invasion of lung parenchyma

T3

Tumour involves ipsilateral pleura (parietal or visceral pleura), with at least one of the following:

  • invasion of endothoracic fascia
  • invasion into mediastinal fat
  • solitary focus of tumour invading soft tissues of the chest wall
  • non‐transmural involvement of the pericardium

T4

Tumour involves ipsilateral pleura (parietal or visceral pleura), with at least one of the following:

  • chest wall, with or without associated rib destruction (diffuse or multifocal)
  • peritoneum (via direct transdiaphragmatic extension)
  • contralateral pleura
  • mediastinal organs (oesophagus, trachea, heart, great vessels)
  • vertebra, neuroforamen, spinal cord
  • internal surface of the pericardium (transmural invasion with or without a pericardial effusion)

N - regional lymph nodes

N value Description

NX

Regional lymph nodes cannot be assessed

N0

No regional lymph node metastasis

N1

Metastases to ipsilateral intrathoracic lymph nodes (includes ipsilateral bronchopulmonary, hilar, subcarinal, paratracheal, aortopulmonary, paraesophageal, peridiaphragmatic, pericardial fat pad, intercostal and internal mammary nodes)

N2

Metastases to contralateral intrathoracic lymph nodes. Metastases to ipsilateral or contralateral supraclavicular lymph nodes

M - distant metastasis

M value Description

M0

No distant metastasis

M1

Distant Metastasis

TNM pathological classification

pT - primary tumour

The pT and pN categories correspond to the T and N categories. 

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Last edited: 21 December 2022 5:08 pm

Previous Chapter

Carcinoma of skin (excluding eyelid, head and neck, perianal, vulva and penis)

Next Chapter

Breast tumours
  1. Cancer staging guidance sheets
  2. Lip and oral cavity (ICD10 C00, C02-C06)
  3. Malignant melanoma of upper aerodigestive tract (ICD10 C00-06, C10-14, C30-32)
  4. Pharynx (ICD10 C01, C05.1-2, C09, C10.0, C10.2-3, C11-13)
  5. Major salivary glands (ICD10 C07, C08)
  6. Oesophagus including oesophagastric junction (ICD10 C15 & C16.0)
  7. Stomach (ICD10 C16 except C16.0)
  8. Small intestine (ICD10 C17)
  9. Appendix (ICD10 C18.1)
  10. Colon and rectum (ICD10 C18-C20)
  11. Anal canal and perianal skin data (ICD10 C21, C44.5)
  12. Liver (ICD10 C22.0)
  13. Intrahepatic bile ducts (ICD10 C22.1)
  14. Gallbladder (ICD10 C23, C24.0)
  15. Distal extrahepatic bile duct (ICD10 C24.0)
  16. Perihilar bile ducts (ICD10 C24.0)
  17. Ampulla of vater (ICD10 C24.1)
  18. Pancreas (ICD10 C25)
  19. Nasal cavity and paranasal sinuses (ICD10 C30.0, C31.0, C31.1)
  20. Larynx (ICD10 C32.0 C32.1, C32.2, C10.1)
  21. Lung (ICD10 C34)
  22. Thymic tumours (ICD10 C37)
  23. Soft tissues (ICD10 C38.1-2, C47-C49)
  24. Bone (ICD10 C40 & C41)
  25. Malignant melanoma of skin (ICD10 C43, C51.0, C60.9, C63.2)
  26. Merkel cell carcinoma of skin (ICD10 C44 & C63.2)
  27. Skin carcinoma of the head and neck (ICD10 C44.0, C44.2-4)
  28. Carcinoma of skin of the eyelid (ICD10 C44.1)
  29. Carcinoma of skin (excluding eyelid, head and neck, perianal, vulva and penis) (ICD10 C44.5-7, C63.2)
  30. Pleural mesothelioma (ICD10 C45)
  31. Breast tumours (ICD10 C50)
  32. Vulva (ICD10 C51)
  33. Cervix uteri (ICD10 C53)
  34. Uterine sarcomas
  35. Uterus - endometrium (ICD10 C54.1, C55)
  36. Ovarian, fallopian tube and primary peritoneal carcinoma (ICD10 C56, C57, C48.1, C48.2)
  37. Gestational trophoblastic neoplasms (ICD10 C58)
  38. Penis tumours (ICD10 C60)
  39. Prostate tumours (ICD10 C61)
  40. Testis tumours (ICD10 C62)
  41. Kidney tumours (ICD10 C64)
  42. Renal pelvis and ureter tumours (ICD10 C65 & C66)
  43. Urinary bladder tumours (ICD10 C67)
  44. Urethra tumours (ICD10 C68.0)
  45. Carcinoma of conjuctiva (ICD10 C69.0)
  46. Malignant melanoma of conjuctiva (ICD10 C69.0)
  47. Retinoblastoma (ICD10 C69.2)
  48. Malignant melanoma of uvea (ICD10 C69.3, C69.4)
  49. Carcinoma of lacrimal gland (ICD10 C69.5)
  50. Sarcoma of orbit (ICD10 C69.6)
  51. Thyroid gland (ICD10 C73)
  52. Adrenal cortex (ICD10 C74.0)
  53. Chronic lymphocytic leukaemia
  54. Hepatoblastoma (CTYA)
  55. Hodgkins and non-hodgkins lymphoma (ICD10 C81-88)
  56. Medulloblastoma
  57. Multiple myeloma
  58. Neuroblastoma
  59. Neuroendocrine tumours of the foregut
  60. Neuroendocrine tumours of the midgut and hindgut
  61. Non-hodgkin lymphoma (children)
  62. Rhabdomyosarcoma and other soft tissue sarcomas (CTYA)
  63. Wilms tumour of the kidney