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Multiple myeloma

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Introduction

This is the data sheet for TNM 8th edition staging of multiple myeloma.

Revised international staging system (R-ISS)

Stage

Description

Stage 1

Early-stage myeloma. Pts with ISS-1 (serum β2-microblobulin level <3.5 mg/L and serum albumin level ≥3.5 g/dL), no high-risk cytogenetic abnormalities in iFISH [such as del(17p) and/or t(4;14) and/or t(14;16)] and normal LDH levels (below the upper limit of normal).

Stage 2

Intermediate-stage myeloma. Not R-ISS Stage 1 or Stage 3
 

Stage 3

Advanced myeloma. Pts with ISS-3 (serum β2-microglobulin level >5.5 mg/L) and either high-risk cytogenetic abnormalities in iFISH or elevated LDH levels.

The R-ISS is based on the assessment of: beta 2-microglobulin (ß2-M), albumin, iFISH, (interphase fluorescence in situ hybridization) and LDH (lactate dehydrogenase)

Online multiple myeloma prognosis R-ISS online calculator.

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Last edited: 15 February 2023 4:19 pm

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