Part of Cancer staging guidance sheets
Retinoblastoma (ICD10 C69.2)
Introduction
This is the data sheet for TNM 8th edition staging of retinoblastoma (ICD10 C69.2).
For more detailed information regarding TNM staging, please see pages 226-229 of the UICC TNM 8 book or visit the Wiley and UICC website.
Stage groupings
Clinical Stage
|
Stage Group |
T stage |
N stage |
M stage |
|---|---|---|---|
|
Stage I |
T1, T2, T3 |
N0 |
M0 |
|
Stage II |
T4a |
N0 |
M0 |
|
Stage III |
T4b |
N0 |
M0 |
|
Any T |
N1 |
M0 |
|
|
Stage IV |
Any T |
Any N |
M1 |
Pathological Stage
|
Stage I |
T1, T2, T3 |
N0 |
M0 |
|---|---|---|---|
|
Stage II |
T4 |
N0 |
M0 |
|
Stage III |
Any T |
N1 |
M0 |
|
Stage IV |
Any T |
Any N |
M1 |
TNM clinical classification
T - primary tumour
| T value | Description |
|---|---|
|
TX |
Primary tumour cannot be assessed. |
|
T0 |
No evidence of primary tumour. |
|
T1 |
Tumour confined to the retina with subretinal fluid no more than 5 mm from the base of any tumour, without retinal detachment T1a - No tumour in either eye is greater than 3 mm in largest dimension or located closer than 1.5 mm to the optic nerve or fovea T1b - At least one tumour is greater than 3 mm in largest dimension or located closer than 1.5 mm to the optic nerve or fovea. No retinal detachment or subretinal fluid beyond 5 mm from the base of the tumour |
|
T2 |
Tumours with vitreous or subretinal seeding or retinal detachment T2a - tumour with subretinal fluid more than 5 mm from the base of any tumour T2b - Tumour with vitreous and/or subretinal seeding |
|
T3 |
Severe intraocular disease T3a - Phthisis or prephthisis bulbi T3b - Invasion of: choroid, pars plana, ciliary body, lens, zonules, iris or anterior chamber T3c - Raided intraocular pressure with neovascularization and/or buphthalmos T3d - Hyphema and or massive vitreous haemorrhage T3e - Aseptic orbital cellulitis |
|
T4 |
Extraocular tumour T4a - Invasion of optic nerve or orbital tissues T4b - Extraocular invasion with proptosis and/or orbital mass |
N - regional lymph nodes
| N value | Description |
|---|---|
|
NX |
Regional lymph nodes cannot be assessed |
|
N0 |
No regional lymph node metastasis |
|
N1 |
Regional lymph node metastasis |
M - distant metastasis
| M value | Description |
|---|---|
|
M0 |
No distant metastasis |
|
M1 |
Distant Metastasis M1a - Single or multiple metastasis to sites other than CNS or brain M1b - Metastasis to the CNS including brain |
TNM pathological classification
pT - primary tumour
| pT value | Description |
|---|---|
|
pTX |
Primary tumour cannot be assessed |
|
pT0 |
No evidence of primary tumour |
|
pT1 |
Tumour confined to eye with no optic nerve or choroidal invasion |
|
pT2 |
Tumour with intraocular invasion pT2a - Focal choroidal invasion and pre‐ or intralaminar invasion of the optic nerve head pT2b - Tumour invasion of stroma of iris and/or trabecular meshwork and/or Schlemm’s canal |
|
pT3 |
Tumour with significant local invasion pT3a - Choroidal invasion larger than 3 mm in diameter or multiple foci of invasion totalling more than 3 mm or any full‐thickness involvement pT3b - Retrolaminar invasion of optic nerve without invasion of transected end of optic nerve pT3c - Partial‐thickness involvement of sclera within the inner two‐thirds pT3d - Full‐thickness invasion into outer third of the sclera and/or invasion into or around emissary channels |
|
pT4 |
Extraocular extension: Tumour invades optic nerve at transected end, in meningeal space around the optic nerve, full‐thickness invasion of the sclera with invasion of the episclera, adipose tissue, extraocular muscle, bone, conjunctiva, or eyelid. |
N - regional lymph nodes
| pN value | Description |
|---|---|
|
pNX |
Regional lymph nodes cannot be assessed |
|
pN0 |
No regional lymph node involvement |
|
pN1 |
Regional lymph node involvement |
M - distant metastasis
| pM value | Description |
|---|---|
|
cM0 |
No distant metastasis |
|
pM1 |
Distant Metastasis pM1a - Single or multiple metastasis to sites other than CNS pM1b - Metastasis to CNS parenchyma or CSF fluid |
Last edited: 14 June 2023 2:01 pm
